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March 2, 2005New England Journal of MedicineOpen Access

Quantitative Determinants of the Outcome of Asymptomatic Mitral Regurgitation

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Why the study?

Does quantitative grading of mitral regurgitation predict clinical outcomes in patients with asymptomatic mitral regurgitation?

Population

Patients with asymptomatic mitral regurgitation

Design

Cohort

Authors

Maurice Enríquez-Sarano
Maurice Enríquez-SaranoCardiac Imaging
JAJean-François AviérinosStructural Heart DiseaseDMDavid Messika‐ZeitounCardiac Imaging

Discussion

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Implication

Supports quantitative MR grading for risk stratification in asymptomatic patients; leaves open whether ERO-guided early surgery improves outcomes.

Structured PICO

Does quantitative grading of mitral regurgitation predict clinical outcomes in patients with asymptomatic mitral regurgitation?

P
Population
Patients with asymptomatic mitral regurgitation
I
Intervention
Quantitative grading of mitral regurgitation (specifically effective regurgitant orifice)
O
Outcome
Clinical outcome

An effective regurgitant orifice of ≥40 mm² in asymptomatic mitral regurgitation is a strong predictor of adverse clinical outcomes, warranting early surgical intervention.

Cite This Study

Enriquez‐Sarano et al. (2005) studied this question.

synapsesocial.com/papers/69dc2228ce788f95bfb6505ehttps://doi.org/10.1056/nejmoa041451

Topics

Mitral valve interventionHeart failureHFrEF treatmentAtrial fibrillationPersistent AF management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Grading of Mitral Regurgitation by Quantitative Doppler Echocardiography1997 · 191 citations
  2. 2Very Long-Term Survival and Durability of Mitral Valve Repair for Mitral Valve Prolapse2001 · 536 citations
  3. 3Ischemic Mitral Regurgitation2001 · 1,434 citations
  4. 4Early Surgery in Patients With Mitral Regurgitation Due to Flail Leaflets1997 · 242 citations