What question did this study set out to answer?

Examine the reciprocal interactions between gut microbiota and the innate immune system and delineate their role in driving autoimmune pathogenesis.

February 21, 2020Frontiers in ImmunologyOpen Access

Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases

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Review reveals gut microbiota crosstalk with innate immunity across autoimmune disorders, suggesting dysbiosis drives inflammatory pathogenesis.

Examine the reciprocal interactions between gut microbiota and the innate immune system and delineate their role in driving autoimmune pathogenesis.
Synthesized molecular and immunological literature examining mucosal homeostasis and innate immune cell compartments.
Evaluated clinical and mechanistic evidence linking microbial dysbiosis to autoimmune conditions, specifically rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus.
Gut microbiota regulates the balance between immune tolerance and host defense via direct crosstalk with gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes.
Disruption of microbial equilibrium (dysbiosis) impairs innate immune regulation and is mechanistically linked to the onset and progression of systemic autoimmune diseases.

Jiao et al. (2020) studied this question.

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Review reveals gut microbiota crosstalk with innate immunity across autoimmune disorders, suggesting dysbiosis drives inflammatory pathogenesis.