April 6, 2007Medical Engineering & Physics
Non-Newtonian models for molecular viscosity and wall shear stress in a 3D reconstructed human left coronary artery
Population
3D reconstructed human left coronary artery acquired using geometrically correct 3D intravascular ultrasound
Comparison
Seven non-Newtonian molecular viscosity models vs Newtonian molecular viscosity model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
These models may refine coronary CFD accuracy; leaves open clinical translation pending human validation.
Structured PICO
P
Population
3D reconstructed human left coronary artery acquired using geometrically correct 3D intravascular ultrasound (3D IVUS)
I
Intervention
Seven non-Newtonian molecular viscosity models (including Power Law, Generalized Power Law, Carreau, Casson, Modified Cross, and Walburn-Schneck)
C
Comparator
Newtonian molecular viscosity model
O
Outcome
Molecular viscosity, local and global non-Newtonian importance factors, wall shear stress (WSS) and wall shear stress gradient (WSSG)surrogate
The Power Law and Generalized Power Law non-Newtonian models provide satisfactory approximations for molecular viscosity and wall shear stress in human left coronary artery computational models.
Cite This Study
Soulis et al. (2007) studied this question.