Why the study?
Do peak CK-MB and peak troponin I levels prognosticate in-hospital mortality in patients with acute myocardial infarction?
Do peak CK-MB and peak troponin I levels prognosticate in-hospital mortality in patients with acute myocardial infarction?
Peak CK-MB provides slightly higher incremental prognostic value for in-hospital mortality than peak troponin I in patients with acute myocardial infarction.
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May refine AMI mortality risk stratification; leaves open whether CK-MB adds actionable value beyond troponin in prospective models.
Both peak CK-MB and peak troponin I levels are independently associated with in-hospital mortality in this large contemporary database of AMI patients treated in routine practice. Peak marker values slightly improved model performance in prognosticating in-hospital mortality; the incremental value was higher with CK-MB than with troponin I. These findings may help to guide future risk stratification algorithms and contribute to more efficient use of serial cardiac marker measurements in clinical practice.
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Chin et al. (2012) studied this question.
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