Association Between Minor Elevations of Creatine Kinase-MB Level and Mortality in Patients With Acute Coronary Syndromes Without ST-Segment Elevation
Why the study?
Does peak CK-MB level elevation predict mortality in patients with acute coronary syndromes without ST-segment elevation?
Population
8250 patients with acute coronary syndromes without ST-segment elevation who had at least 1 CK-MB sample…
Comparison
Peak CK-MB level elevation vs Normal peak CK-MB levels
Design
Cohort
Follow-up
30 days and 6 months
Authors
Discussion
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Member takes
Implication
Minor CK-MB elevations were associated with higher mortality in NSTE-ACS; supports risk stratification but leaves open diagnostic threshold changes.
Structured PICO
Does peak CK-MB level elevation predict mortality in patients with acute coronary syndromes without ST-segment elevation?
P
Population
8250 patients with acute coronary syndromes without ST-segment elevation who had at least 1 CK-MB sample collected during their index hospitalization
I
Intervention
Peak CK-MB level elevation (categories: >1-2, >2-3, >3-5, >5-10, or >10 times the upper limit of normal)
C
Comparator
Normal peak CK-MB levels (0-1 times the upper limit of normal)
O
Outcome
Mortality at 30 days and 6 monthshard clinical
Even minor elevations of CK-MB (just above normal) are strongly associated with increased 30-day and 6-month mortality in patients with NSTE-ACS, indicating they should be considered indicative of myocardial infarction.
Cite This Study
John H. Alexander (2000) studied this question.