What question did this study set out to answer?

This research aims to determine the relationship between PCSK6 levels and respiratory outcomes in patients with pulmonary fibrosis.

April 22, 2026Respiratory ResearchOpen Access

PCSK6 and clinical outcomes in the Pulmonary Fibrosis Foundation Patient Registry

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Authors

KBKRISTIN BERGER SKSam KonkolUniversity of Virginia SMShwu-Fan MaUniversity of Virginia

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Implication

Observational study evaluates PCSK6 associations with respiratory outcomes in pulmonary fibrosis, suggesting a role in idiopathic pulmonary fibrosis survival.

Key Points

This research aims to determine the relationship between PCSK6 levels and respiratory outcomes in patients with pulmonary fibrosis.
Measured PCSK6 concentration in plasma from 428 participants with fibrotic ILD using ELISA.
Analyzed associations with respiratory outcomes and survival using adjusted Cox models.
Examined PCSK6 expression in fibrotic lungs through single-cell RNA sequencing (scRNA-seq).
PCSK6 levels were not significantly linked with key respiratory outcomes in the overall cohort.
In participants with idiopathic pulmonary fibrosis, higher PCSK6 was associated with reduced survival.
High PCSK6 expression was noted in specific fibroblasts within fibrotic lung tissues.

Cite This Study

BERGER et al. (2026) studied this question.

synapsesocial.com/papers/69e8656e6e0dea528dde9ebe https://doi.org/10.1186/s12931-026-03642-1

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Implication

Observational study evaluates PCSK6 associations with respiratory outcomes in pulmonary fibrosis, suggesting a role in idiopathic pulmonary fibrosis survival.

PCSK6 and clinical outcomes in the Pulmonary Fibrosis Foundation Patient Registry

Discussion

Member takes

Implication

Key Points

Cite This Study

PCSK6 and clinical outcomes in the Pulmonary Fibrosis Foundation Patient Registry

Discussion

Member takes

Implication

Key Points

Cite This Study

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