Evaluation of differentiation of the umbilical cord blood-derived mesenchymal stem cells into male germ-line cells in two-dimensional and three-dimensional scaffolds containing naringin.

Arian Azimi; Arian Ehterami; Sepehr Zamani; Seyede Nazanin Aghayan; Seyed Meysam Yekesadat; Fariborz Sharifianjazi; Sina Sohrabi; Morteza Alizadeh; Majid Salehi

doi:10.22038/ijbms.2026.88928.19199

January 1, 2026Open Access

Evaluation of differentiation of the umbilical cord blood-derived mesenchymal stem cells into male germ-line cells in two-dimensional and three-dimensional scaffolds containing naringin.

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Key Points

The research aims to evaluate the differentiation potential of umbilical cord blood-derived mesenchymal stem cells into male germ-like cells using different scaffold designs.
Utilized 2D and 3D scaffolds containing naringin to promote cell differentiation.
Assessed cell differentiation efficacy in 3D PLLA/GNF/Nar scaffolds.
Evaluated microenvironment conditions for optimal cellular development.
3D PLLA/GNF/Nar scaffold significantly enhanced differentiation into male germ-like cells.
The favorable microenvironment in 3D scaffolds suggests improved outcomes compared to 2D scaffolds.
Findings indicate potential applications in reproductive tissue engineering.

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Implication

Evaluation demonstrates effective germ-cell differentiation in umbilical cord blood-derived cells, suggesting advancements in tissue engineering.

Abstract

The 3D PLLA/GNF/Nar scaffold creates a favorable microenvironment that effectively promotes UCB-MSC differentiation into male germ-like cells, representing a promising platform for reproductive tissue engineering applications.

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Cite This Study

Azimi et al. (2026) studied this question.

synapsesocial.com/papers/69e8656e6e0dea528dde9f49 https://doi.org/10.22038/ijbms.2026.88928.19199

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Evaluation of differentiation of the umbilical cord blood-derived mesenchymal stem cells into male germ-line cells in two-dimensional and three-dimensional scaffolds containing naringin.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Evaluation of differentiation of the umbilical cord blood-derived mesenchymal stem cells into male germ-line cells in two-dimensional and three-dimensional scaffolds containing naringin.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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