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April 1, 2026JHEP ReportsOpen Access

Haemodynamic alterations associated with hepatic vascular malformations in hereditary haemorrhagic telangiectasia: a cohort study

Pernille Darre HAAHR M K Poulsen Jens KJELDSEN M Omar Simon Tholander Annette Dam Fialla Anette Drøhse Kjeldsen

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Key Points

The study aimed to evaluate the prevalence of high-output heart failure and its relationship with hepatic vascular malformation severity in hereditary haemorrhagic telangiectasia patients.
Cohort study design involving adult patients with hereditary haemorrhagic telangiectasia from the national Danish database.
Participants underwent clinical evaluation, hepatic Doppler ultrasound, and transthoracic echocardiography to assess HVM severity and haemodynamics.
Grading of hepatic vascular malformations was based on the Buscarini classification.
High-output heart failure was observed in 6.6% of patients, predominantly among those with severe hepatic vascular malformations.
Cardiac index showed a positive correlation with HVM severity, increasing with each grade of malformation.
Transthoracic echocardiography was identified as a valuable non-invasive tool for detecting risk of haemodynamic complications.

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Implication

Cohort study examines haemodynamic changes in patients with hereditary haemorrhagic telangiectasia, indicating significant clinical implications.

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Cite This Study

HAAHR et al. (2026) studied this question.

synapsesocial.com/papers/69e865926e0dea528ddea18b https://doi.org/10.1016/j.jhepr.2026.101867

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