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April 19, 2026Movement Disorders Clinical PracticeOpen Access

Continuous Apomorphine Infusion in Multiple System Atrophy Real‐World Insights From a French Nationwide Retrospective Cohort

Simon Lamy Frédérique Leh Alexandra Foubert‐Samier Soizic Leguy Bonnet Guillaume Baille Margherita Fabbri Margaux Dunoyer Lise Mantisi Caroline Giordana Anaïs El Ouartassi Olivier Rascol Wassilios G. Meissner David Bendetowicz Marie Vanel David Grabli Fabienne Ory‐Magne Sophie Drapier

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Key Points

This study aims to evaluate the clinical efficacy of continuous apomorphine infusion in managing symptoms of multiple system atrophy.
Retrospective cohort analysis of MSA patients
Assessment of clinical response to continuous apomorphine infusion
Evaluation of tolerability in the selected patient population
Patients experienced short-term clinical benefits from continuous apomorphine infusion
Acceptable levels of tolerability observed among treated patients
Specific improvements noted in motor fluctuations and dopaminergic responsiveness

Implication

Retrospective cohort reveals apomorphine improves motor control in multiple system atrophy patients, suggesting efficacy.

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Cite This Study

Lamy et al. (2026) studied this question.

synapsesocial.com/papers/69e865fd6e0dea528ddea5cd https://doi.org/10.1002/mdc3.70644

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A delphi consensus statement about French practical management of continuous apomorphine infusion in patients with Parkinson's disease and motor fluctuationsClinical Guideline · 2025 · 5 citations
2Subcutaneous Apomorphine Infusion Initiation Is Associated with Impulse Control Disorder Attenuation in Advanced Parkinson's Disease Patients: Insights from the French NS ‐Park CohortCohort Study · 2025 · 9 citations
3Levodopa–carbidopa intestinal gel for multiple system atrophy with motor fluctuations: a case series2025 · 1 citations
4Biochemical and nutritional changes during continuous subcutaneous apomorphine infusion in advanced Parkinson’s disease: findings from an observational cohortCohort Study · 2026
5Case Report: Sublingual Levodopa in Advanced Multiple System Atrophy.Case Report · 2026

More related papers

Is Dysphagia in Multiple System Atrophy Responsive to Levodopa? Results from a Retrospective Study.2025
Efficacy and safety of apomorphine in the treatment of Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials2026
Diagnostic symptoms, treatment patterns, and healthcare resource utilization in multiple system atrophy in the United States2025

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