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April 22, 2026Open Access

Assessment of Haptoglobin, Creatinine and Novel Markers of AKI in Homozygous and Heterozygous Sickle Cell Disease Patients in Ekiti State.

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Authors

KSKazeem SulemanOOOdeyinka OdewusiAOAdeola Oluboyo

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Overview

Assesses kidney injury markers in sickle cell disease patients, indicating significant renal changes during crises.

Key Points

  • To evaluate serum haptoglobin, creatinine, and acute kidney injury markers in sickle cell disease patients.
  • Measured serum haptoglobin, creatinine, and AKI markers in 66 subjects, including 37 SCD patients.
  • Utilized ELISA for marker quantification and Mindray BC-5000 for full blood count analysis.
  • Correlated demographic data and laboratory results to assess the impact of sickle cell variations.
  • Homozygous SCD subjects showed significantly worse anaemia and higher AKI markers during crises.
  • Total white blood cells correlated positively with creatinine levels in homozygous SCD patients.
  • KIM-1 and NGAL were identified as effective markers of renal injury during both stable and crisis states.

Cite This Study

Suleman et al. (2025) studied this question.

synapsesocial.com/papers/69e8661d6e0dea528ddea7cdhttps://doi.org/10.71637/tnhj.v26i1.1144
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Also Consider

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  3. 3Biomarker Profiles in Distinct Clinical Subphenotypes of Sickle Cell Disease: An Explorative Study2026
  4. 4Evaluation of renal function of sickle cell children in Libreville by estimation of glomerular creatinine-cystatin C filtration rate: prevalence of acute kidney injury and associated factors2024 · 1 citations
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