Randomized controlled trial compares pain management effectiveness in facial rejuvenation, suggesting the need for improved study design.
Compound lidocaine cream demonstrated superior analgesic efficacy in this clinical comparison; however, differences in anesthetic concentration, application technique, and lack of participant blinding should be considered when interpreting these findings. Larger studies with standardized dosing and blinding are warranted.
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Liu et al. (2026) studied this question.
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