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The aim is to enhance acetate production in Synechocystis PCC 6803 by overexpressing specific CBB-cycle enzymes.

April 22, 2026Algal ResearchOpen Access

Further enhanced acetate production by overexpressing selected CBB-cycle enzymes in an engineered Synechocystis PCC 6803 strain

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The aim is to enhance acetate production in Synechocystis PCC 6803 by overexpressing specific CBB-cycle enzymes.
Overexpressed aldolase and its combinations with fructose-1,6/sedoheptulose-1,7-bisphosphatase or transketolase.
Knocked out CP12, a regulatory protein, in specific engineered strains.
Measured acetate production levels to assess enzyme effectiveness.
Strain overexpressing FBA showed a 1.5-fold increase in acetate production.
Combination of FBA and FBP/SBPase enhanced acetate, but not significantly more than FBA alone.
Overexpression of FBA and TK increased acetate only in the ΔCP12 strain.

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Cyanobacteria overexpress enzymes to increase acetate production, indicating metabolic optimization potential.

Roussou et al. (2026) studied this question.

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