What question did this study set out to answer?

To evaluate the efficacy of a lidocaine-loaded alginate, CMC, and PEO electrospun film for reducing postoperative pain and adhesions.

April 22, 2026MedicinaOpen Access

Effects of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber Film on Postoperative Pain and Peritoneal Adhesion in a Rat Model

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This investigation reveals lidocaine-loaded film reduces postoperative pain and adhesions in rats, suggesting effective dual therapy.

To evaluate the efficacy of a lidocaine-loaded alginate, CMC, and PEO electrospun film for reducing postoperative pain and adhesions.
Comparison of saline control, free lidocaine, drug-free ACPE film, and lidocaine-loaded ACPE film across four groups of rats.
Assessment of mechanical withdrawal threshold after incision, along with histological evaluation of adhesions and inflammation.
Use of the Moreno system to score adhesions.
Lidocaine-loaded ACPE film significantly improved mechanical withdrawal threshold versus all other treatments.
Lower adhesion scores were observed in the lidocaine film group, indicating reduced adhesion formation.
Histological analysis showed decreased inflammatory cell infiltration and collagen deposition in the film-treated group.

Kim et al. (2026) studied this question.

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