A Metaproteomic Platform for Integrated Host-Pathogen-Microbiota Profiling in Zebrafish Larvae

Key Points

• The research aims to develop an analytical strategy for profiling interactions among hosts, pathogens, and microbiota.
• Implemented a global metaproteomic workflow.
• Simultaneously profiled various biological compartments.
• Utilized zebrafish larvae as the experimental model.
• Demonstrated effective resolution of host, pathogen, and microbiota components.
• Highlighted complex interactions within the biological systems analyzed.
• Showed potential applications in understanding disease mechanisms.