What question did this study set out to answer?

To evaluate the reliability of tissue transglutaminase antibody levels as a confirmatory test for coeliac disease in children without a biopsy.

April 22, 2026DiagnosticsOpen Access

Exploring Tissue Transglutaminase Antibodies as a Confirmatory Tool for Diagnosing Coeliac Disease in Children

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Retrospective analysis assesses tissue transglutaminase antibody use for diagnosing coeliac disease, suggesting improved diagnostics for children.

To evaluate the reliability of tissue transglutaminase antibody levels as a confirmatory test for coeliac disease in children without a biopsy.
Retrospective analysis of medical data from children diagnosed with coeliac disease from January 2013 to June 2025.
Assessment of tissue transglutaminase antibody levels in second blood samples.
Comparison of results with anti-endomysial antibody test outcomes.
Out of 185 patients, 49 used a no-biopsy approach with 93.9% having TGA > 10 × ULN.
In biopsy-confirmed cases, 57.4% had initial TGA > 10 × ULN.
Secondary serology revealed 88.2% of previously diagnosed patients maintained TGA > 10 × ULN.

Rižnik et al. (2026) studied this question.

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Retrospective analysis assesses tissue transglutaminase antibody use for diagnosing coeliac disease, suggesting improved diagnostics for children.