Intraprostatic paraganglioma (PGL) is a rare neuroendocrine tumor arising from chromaffin cells and poses diagnostic and management challenges. We report a 63-year-old man with Grade Group 3 prostate adenocarcinoma who underwent robotic radical prostatectomy and was incidentally found to have a 1.5 mm intraprostatic PGL on final pathology. The patient had no catecholamine-related symptoms, and postoperative plasma metanephrines were normal, consistent with a nonfunctional tumor. Immunohistochemical staining supported the diagnosis. The patient elected surveillance and remains asymptomatic. This case highlights the variable presentation of prostatic PGL and emphasizes the role of pathologic evaluation, biochemical testing, and individualized management strategies.
Gonzalez et al. (Wed,) studied this question.