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April 22, 2026Journal of Nephrology

The association between plasma aldosterone level, transtubular potassium gradient, or their ratios and causes of hyperkalemia in the outpatient setting

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Authors

TWThanawan WuthapanichPPPran PhakdeekitcharoenCSChadapa Sevamontree

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Overview

Cohort study evaluates plasma aldosterone and potassium gradient's role in hyperkalemia causes, indicating diagnostic implications.

Key Points

  • The aim is to assess how plasma aldosterone and transtubular potassium gradient help identify causes of hyperkalemia.
  • Conducted a prospective cohort study with patients from an outpatient clinic.
  • Analyzed plasma aldosterone levels and transtubular potassium gradients.
  • Classified causes of hyperkalemia into drug-induced, diabetes-related, and CKD-related.
  • Hyperkalemia patients had a significantly higher mean serum potassium level compared to controls.
  • Sensitivity and specificity of aldosterone/potassium ratios were comparable in distinguishing hyperkalemia causes.
  • Identified a notable range of potassium gradients particularly in CKD-related hyperkalemia.

Cite This Study

Wuthapanich et al. (2026) studied this question.

synapsesocial.com/papers/69e866f16e0dea528ddeb41fhttps://doi.org/10.1093/joneph/aajaf041
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