Multidisciplinary management improves neurological outcomes in children with severe neuroimmunological disorders, suggesting benefits of plasma exchange.
TPE appears to be a safe and potentially beneficial intervention for severe or refractory pediatric neuroimmunological disorders. Earlier initiation of TPE was associated with improved neurological outcomes; however, these findings should be interpreted cautiously given the small sample size and heterogeneous disease groups. These findings support integrating TPE into multidisciplinary PICU management and add to the growing evidence supporting its use in pediatric neuroimmunology.
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Şik et al. (2026) studied this question.
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