Enantioselective 3 + 2 Cycloaddition of Spirocyclopropyloxindoles with 2-(phthalimido)acrylates: Access to Spirocyclopentaneoxindoles

Key Points

• This research aims to develop a stereoselective synthetic method for chiral spirocyclopentane oxindoles.
• Conducted a [3 + 2] cycloaddition reaction with spirocyclopropyloxindoles and 2-(phthalimido)acrylates.
• Focused on optimizing reaction conditions to enhance enantioselectivity.
• Synthesized various spirocyclopentane oxindoles for evaluation.
• Significantly improved enantioselectivity compared to traditional methods.
• Successfully generated diverse spirocyclopentane oxindoles.
• Demonstrated the potential application in synthesizing bioactive compounds.