Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria‐Induced Apoptosis Pathway

Key Points

• This study aims to explore the effectiveness of exportin 1 inhibition in combination with venetoclax for treating myelodysplastic syndrome.
• Inhibition of exportin 1 using a specific inhibitor.
• Combination treatment with venetoclax.
• Assessment of apoptotic pathways, particularly mitochondrial pathways.
• Exportin 1 inhibition combined with venetoclax significantly induces apoptosis in myelodysplastic syndrome cells.
• The treatment demonstrates enhanced efficacy compared to either treatment alone.