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April 22, 2026Current Issues in Molecular BiologyOpen Access

Management of Pregnancy in Women with Inflammatory Bowel Disease: Positioning Janus Kinase Inhibitors Within Current Evidence

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Authors

DCDario ColacurciGoethe University FrankfurtRPRaffaele PellegrinoUniversity of Campania "Luigi Vanvitelli"ALAlessia LamartUniversity of Campania "Luigi Vanvitelli"

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Implication

This review evaluates the safety of janus kinase inhibitors in managing active inflammatory bowel disease during pregnancy, suggesting further research is needed.

Key Points

  • This review aims to assess the use and safety of janus kinase inhibitors in managing inflammatory bowel disease during pregnancy.
  • Examined existing data related to the use of janus kinase inhibitors in pregnancy.
  • Analyzed the quality and heterogeneity of available evidence regarding these therapies.
  • Current data on janus kinase inhibitors is heterogeneous and of low quality.
  • No current recommendations can be made for their use during pregnancy due to safety concerns.
  • Further research through prospective registries and observational studies is necessary.

Cite This Study

Colacurci et al. (2026) studied this question.

synapsesocial.com/papers/69e8677e6e0dea528ddeb99chttps://doi.org/10.3390/cimb48040421
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pregnancy Outcomes in Patients Treated with Upadacitinib: Analysis of Data from Clinical Trials and Postmarketing Reports2024 · 36 citations
  2. 2The Use of Metronidazole During Pregnancy: A Review of Evidence2015 · 71 citations
  3. 3Laboratory reference intervals during pregnancy, delivery and the early postpartum period2009 · 139 citations
  4. 4Fetal exposure to tofacitinib during the first trimester: A healthy newborn case report2021 · 20 citations