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May 11, 1999Proceedings of the National Academy of SciencesOpen Access

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

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Authors

AMAllen S. MandirJohns Hopkins University
Serge Przedborski
Serge PrzedborskiBoston UniversityVJVernice Jackson‐LewisColumbia University Irving Medical Center

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Mandir et al. (1999) studied this question.

synapsesocial.com/papers/69e931fa5eea8a07da94b736https://doi.org/10.1073/pnas.96.10.5774
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poly(ADP-ribosylation) of a DNA topoisomerase.1983 · 144 citations
  2. 2Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine1995 · 613 citations
  3. 3Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells1997 · 1,060 citations