What question did this study set out to answer?

The research aims to identify non-invasive biomarkers related to adiposity in children via DNAm-derived protein EpiScores.

April 23, 2026Clinical Epigenetics0 citationsOpen Access

Non-invasive epigenetic protein signatures associated with childhood obesity

ERErika M. RichterClemson University PPPriyadarshni PatelEmory University JBJeganathan R. BabuClemson University

Key Points

The research aims to identify non-invasive biomarkers related to adiposity in children via DNAm-derived protein EpiScores.
Analyzed salivary DNA methylation to derive protein EpiScores.
Investigated molecular signatures in children associated with obesity.
Considered the impact of socioeconomic status on obesity risk.
EpiScores effectively capture molecular signatures reflecting adiposity in children.
Salivary analyses can detect early metabolic regulation changes.
Findings suggest a connection between biological factors and socioeconomic patterns in obesity.

Abstract

Salivary DNAm-derived protein EpiScores capture biologically coherent and socially patterned molecular signatures of adiposity in children. These DNAm-based proxies provide a noninvasive means of detecting early alterations in metabolic regulation and may inform future longitudinal studies integrating biological and socioeconomic determinants of obesity risk.

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