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April 23, 2026OncoImmunologyOpen Access

Spatial transcriptomics unveils immune cellular ecosystems associated with patient survival in diffuse large B-cell lymphoma

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Authors

ADAlba Diaz-HerreroHPHector F. Pelaez-PrestelLMLucile Massenet-Regad

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Overview

Spatial transcriptomics identifies immune ecosystems affecting survival in diffuse large B-cell lymphoma, suggesting new prognostic tools.

Key Points

  • The aim is to understand how immune cells and malignant cells are organized in diffuse large B-cell lymphoma and how this affects patient survival.
  • Conducted spatial transcriptomics on primary DLBCL tissue sections.
  • Analyzed spatial gene expression patterns and validated key features at the protein level.
  • Developed prognostic scores based on identified cellular ecosystems.
  • Identified six distinct spatially organized cellular ecosystems with varying immune compositions.
  • Demonstrated divergent clinical associations despite similar immune cell abundances.
  • Prognostic scores based on cellular architecture effectively stratified patient survival in over 1000 cases.

Cite This Study

Diaz-Herrero et al. (2026) studied this question.

synapsesocial.com/papers/69e9b80e85696592c86eb88ahttps://doi.org/10.1080/2162402x.2026.2660418
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