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December 8, 2025BloodOpen Access

Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression

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Authors

GNGiulia NotarpietroRDRossana DaprileASAnna Scattone

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Overview

Spatial transcriptomic analysis reveals distinct immune cell roles and tumor microenvironment changes in chronic lymphocytic leukemia.

Key Points

  • This research aims to explore the evolution of the tumor microenvironment in chronic lymphocytic leukemia during disease progression.
  • Performed Digital Spatial Profiling on 17 FFPE CLL lymph nodes
  • Characterized tumor and immune cells in distinct microanatomical areas
  • Used Gene Ontology analysis on differentially expressed genes
  • Identified changes in T lymphocyte and macrophage transcriptional profiles across clinical CLL stages
  • Observed upregulation of genes associated with proliferation and inflammation in tumor cells
  • Found varying pathways related to immune response and cellular function among CLL clinical subgroups.

Cite This Study

Notarpietro et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d862https://doi.org/10.1182/blood-2025-3880
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spatial transcriptomics unveils immune cellular ecosystems associated with patient survival in diffuse large B-cell lymphoma2024
  2. 2Role of the immune microenvironment in the clonal evolution of chronic lymphocytic leukemia2025
  3. 3High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma2024 · 10 citations
  4. 4Spatial transcriptomics unveils immune cellular ecosystems associated with patient survival in diffuse large B-cell lymphoma2026
  5. 5Abstract A057: Spatially resolved single cell atlas reveals niche-driven transcriptional rewiring across a B-cell lymphoma continuum and gives insights into transformation2026