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December 8, 2025BloodOpen Access

Role of the immune microenvironment in the clonal evolution of chronic lymphocytic leukemia

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Authors

VRVictoria RognessCGChristine GruessnerAWAdrian Wiestner

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Overview

Analyzes clonal evolution and genomic alterations in chronic lymphocytic leukemia, highlighting implications of immune composition.

Key Points

  • To investigate the differences in clonal architecture and immune composition between peripheral blood and lymph nodes in CLL patients.
  • Performed whole exome sequencing and bulk RNA sequencing on paired lymph node and blood samples from CLL patients.
  • Analyzed somatic variants and clonal architecture using SuperFreq and cancer cell fraction methods.
  • Classified genomic alterations and assessed compartmentalization based on clonal distribution.
  • Identified significant heterogeneity in clonal architecture across compartments in CLL patients.
  • Found a predominance of TP53 mutations and genomic alterations linked to clonal evolution.
  • Noted a correlation between evolving clones and immune composition, with implications for CLL progression.

Cite This Study

Rogness et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8a6https://doi.org/10.1182/blood-2025-5653
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Also Consider

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  1. 1Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression2025
  2. 2Acquisition of CLL-like epigenetic and transcriptomic states in low-count MBL2025
  3. 3Therapy-driven clonal dynamics in chronic lymphocytic leukemia2026 · 1 citations
  4. 4BTK inhibition drives mobilization and compartmental shifts of CLL subclones2025
  5. 5Abstract A042: Genetic and microenvironmental determinants of site-to-site heterogeneity in follicular lymphoma2026