What question did this study set out to answer?

The research aims to optimize the manufacturing process of AMG 193 by investigating the mechanistic details of borylation reactions.

Mechanistic Investigation of a Domino N–H and C–H Borylation in the Manufacture of AMG 193

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Investigation reveals improved C–H activation and reduced iridium use in AMG 193 manufacture, suggesting efficient production pathways.

The research aims to optimize the manufacturing process of AMG 193 by investigating the mechanistic details of borylation reactions.
Developed an iridium-catalyzed tandem N–H/C–H borylation procedure
Performed kinetic analysis comparing N–H and C–H activation rates
Utilized in situ reaction monitoring techniques like ReactIR and NMR
Achieved a 10-fold reduction in iridium catalyst usage
Identified that N-boryl functionalization inhibits C–H activation
Established faster rates for N–H activation compared to C–H activation

Wilson et al. (2026) studied this question.

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