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April 23, 2026Andrology0 citations

Emerging Effects of Glucagon‐Like Peptide‐1 Receptor Agonists and Sodium‐Glucose Cotransporter 2 Inhibitors on Male Sexual Hormones and Behaviors: Systematic Review and Meta‐Analysis

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GCGiovanni CoronaCSClotilde SparanoMRMarilina Romeo

Key Points

  • The aim is to explore the effects of GLP1-RAs and SGLT2is on male sexual hormones and behaviors.
  • Conducted a systematic review and meta-analysis of existing data.
  • Focused on studies reporting on GLP1-RAs and SGLT2is impacts on male sexual health.
  • Compared findings related to sexual dysfunction, testosterone levels, and associated behaviors.
  • GLP1-RAs show promise in improving sexual dysfunction and related cardiovascular issues in obese patients.
  • Limited data on SGLT2is prevents definitive conclusions about their effects on male sexual health.
  • Testosterone replacement therapy may be beneficial in conjunction with GLP1-RAs in certain cases.

Abstract

Present data support the use of GLP1-RAs for improving sexual dysfunction, and its underlying CV problems, in obese patients with ED. A combination of TRT and GLP1-RAs can be considered in selected cases. Data on SGLT2is are too limited to draw final conclusions.

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Cite This Study

Corona et al. (2026) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebb96https://doi.org/10.1111/andr.70238
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