This narrative review assesses GLP-1 receptor agonists' effects on sexual function, highlighting knowledge gaps and implications for future research.
Collectively, preclinical evidence supports inhibitory effects of GLP-1 receptor activation on sexual motivation, whereas human findings are limited and reveal heterogeneous outcomes possibly influenced by gender, metabolic status, GLP-1 RA drug type, and psychosocial factors. Further mechanistic and controlled clinical studies are warranted since there seems to be a divergence between preclinical and clinical data.
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Zaher Merhi (2026) studied this question.
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