Rational Engineering of Highly Sensitive and Specific Tyrosinase probe for Guiding Melanoma Surgical Resection

Yifeng Jian; Yongnan Luo; Ke Li; Minghui Yang; Xiang Chen

doi:10.1039/d6cc01628f

January 1, 2026Chemical Communications

Rational Engineering of Highly Sensitive and Specific Tyrosinase probe for Guiding Melanoma Surgical Resection

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Key Points

To develop a sensitive and specific tyrosinase probe for enhancing melanoma resection accuracy.
Design and synthesis of a novel tyrosinase probe (SCy-tyr)
Evaluate selectivity and sensitivity of the probe in detecting tyrosinase activity
Test the probe's effectiveness in a surgical context
The SCy-tyr probe exhibited significantly improved selectivity compared to existing probes
Higher sensitivity in detecting tyrosinase activity was observed
Demonstrated potential to enhance the precision of melanoma surgical resections

Implication

A novel tyrosinase probe enhances detection during melanoma surgical resection, suggesting improved outcomes.

Abstract

The precise detection of tyrosinase activity is crucial for the surgical resection of melanoma. Herein, an novel tyrosinase probe (SCy-tyr) was developed to overcome the limitations of poor selectivity and...

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Cite This Study

Jian et al. (2026) studied this question.

synapsesocial.com/papers/69e9b8d485696592c86ebec5 https://doi.org/10.1039/d6cc01628f

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Rational Engineering of Highly Sensitive and Specific Tyrosinase probe for Guiding Melanoma Surgical Resection

Key Points

Implication

Abstract

Discussion

Cite This Study

Rational Engineering of Highly Sensitive and Specific Tyrosinase probe for Guiding Melanoma Surgical Resection

Key Points

Implication

Abstract

Discussion

Cite This Study

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