Rational Engineering of Highly Sensitive and Specific Tyrosinase probe for Guiding Melanoma Surgical Resection

Puntos clave

• To develop a sensitive and specific tyrosinase probe for enhancing melanoma resection accuracy.
• Design and synthesis of a novel tyrosinase probe (SCy-tyr)
• Evaluate selectivity and sensitivity of the probe in detecting tyrosinase activity
• Test the probe's effectiveness in a surgical context
• The SCy-tyr probe exhibited significantly improved selectivity compared to existing probes
• Higher sensitivity in detecting tyrosinase activity was observed
• Demonstrated potential to enhance the precision of melanoma surgical resections