What question did this study set out to answer?

The study aims to explore how early gestational methionine excess affects the redox stability and adaptability in offspring through metabolic and epigenetic mechanisms.

April 23, 2026Redox BiologyOpen Access

Early-life redox perturbation programs intergenerational redox vulnerability through DAF-16/FOXO and SKN-1/Nrf2 signaling in Caenorhabditis elegans

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Authors

JLJingyimei LiangUniversidade de Vigo YZYuxuan ZhaoUniversidade de Vigo YXYitong XieShenyang Agricultural University

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Implication

This investigation shows that early-life methionine overload damages redox stability in offspring, indicating potential nutritional remedies.

Key Points

The study aims to explore how early gestational methionine excess affects the redox stability and adaptability in offspring through metabolic and epigenetic mechanisms.
Used C. elegans as a model organism.
Examined the effects of dietary methionine excess on offspring in terms of motility, lifespan, and oxidative stress levels.
Investigated metabolic stress response pathways and chromatin remodeling mechanisms, including the role of EGCG intervention.
Offspring exhibited impaired motility, reduced lifespan, and increased oxidative stress levels due to early gestational methionine excess.
Sustained metabolic stress was linked to a disrupted one-carbon metabolism pathway, impairing offspring's redox resilience.
EGCG was effective in restoring metabolic balance and alleviating chromatin and transcriptional limitations.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/69e9b95b85696592c86ec2d2 https://doi.org/10.1016/j.redox.2026.104168

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Implication

This investigation shows that early-life methionine overload damages redox stability in offspring, indicating potential nutritional remedies.

Early-life redox perturbation programs intergenerational redox vulnerability through DAF-16/FOXO and SKN-1/Nrf2 signaling in Caenorhabditis elegans

Discussion

Member takes

Implication

Key Points

Cite This Study

Early-life redox perturbation programs intergenerational redox vulnerability through DAF-16/FOXO and SKN-1/Nrf2 signaling in Caenorhabditis elegans

Discussion

Member takes

Implication

Key Points

Cite This Study

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