What question did this study set out to answer?

This review aims to evaluate the effectiveness and tolerability of pharmacological prophylaxis for adults with a history of treatment failure in migraine management.

April 23, 2026Cephalalgia

Effectiveness and tolerability of pharmacological prophylaxis in migraine patients with prior preventive treatment failure: A systematic review and network meta-analysis of randomized controlled trials

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Authors

MKMalahat KhaliliMcMaster University FHFaraidoon HaghdoostGeneral / Preventive / Lipids ALAmin LiaghatdarIsfahan University of Medical Sciences

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Implication

A systematic review examines the effects of pharmacological prophylaxis in migraine patients with past treatment failures, suggesting potential benefits of therapies.

Key Points

This review aims to evaluate the effectiveness and tolerability of pharmacological prophylaxis for adults with a history of treatment failure in migraine management.
Conducted a systematic review of randomized controlled trials from multiple databases
Included adults diagnosed with chronic or episodic migraine who had previous treatment failures
Performed a network meta-analysis using frequentist random-effects model.
18 trials included, with a total of 7281 participants
CGRP-targeted therapies such as fremanezumab and galcanezumab showed potential benefits in reducing migraine days
Low to moderate certainty evidence indicated increased likelihood of 50% response rate with certain treatments compared to placebo.

Cite This Study

Khalili et al. (2026) studied this question.

synapsesocial.com/papers/69e9b9a285696592c86ec388 https://doi.org/10.1177/03331024261441287

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Implication

A systematic review examines the effects of pharmacological prophylaxis in migraine patients with past treatment failures, suggesting potential benefits of therapies.

Effectiveness and tolerability of pharmacological prophylaxis in migraine patients with prior preventive treatment failure: A systematic review and network meta-analysis of randomized controlled trials

Discussion

Member takes

Implication

Key Points

Cite This Study

Effectiveness and tolerability of pharmacological prophylaxis in migraine patients with prior preventive treatment failure: A systematic review and network meta-analysis of randomized controlled trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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