Cross-coupling of aryl aldehydes and benzyl chlorides enabled by dual N-heterocyclic carbene/cobalt catalysis

Hassan Jomaa; David Martin; Eder Tomás‐Mendivil

doi:10.1039/d6cc01204c

January 1, 2026Chemical Communications

Cross-coupling of aryl aldehydes and benzyl chlorides enabled by dual N-heterocyclic carbene/cobalt catalysis

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Key Points

The aim is to develop a catalytic system that allows for efficient cross-coupling of aryl aldehydes and benzyl chlorides.
Utilized a dual N-heterocyclic carbene/cobalt-salen catalytic system.
Performed direct C-H activation of aldehydes during the reaction.
Achieved successful cross-coupling of aryl aldehydes with benzyl chlorides.
Demonstrated a readily accessible catalytic system that enhances reaction efficiency.

Implication

Demonstrates effective cross-coupling using dual catalysts in organic synthesis, indicating improved reaction efficiency.

Abstract

We have developed a dual N-heterocyclic carbene/cobalt-salen catalytic system for the cross-coupling between aryl aldehydes and benzyl chlorides via direct C-H activation of aldehydes. The catalysts employed are readily accessible...

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Cite This Study

Jomaa et al. (2026) studied this question.

synapsesocial.com/papers/69e9b9a285696592c86ec39e https://doi.org/10.1039/d6cc01204c

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Cross-coupling of aryl aldehydes and benzyl chlorides enabled by dual N-heterocyclic carbene/cobalt catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Cross-coupling of aryl aldehydes and benzyl chlorides enabled by dual N-heterocyclic carbene/cobalt catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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