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The study aims to summarize the molecular mechanisms by which traditional Chinese medicine treats osteoarthritis.

Molecular Mechanisms of Traditional Chinese Medicine in Treating Osteoarthritis

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The study aims to summarize the molecular mechanisms by which traditional Chinese medicine treats osteoarthritis.
Conducted a systematic review of studies from multiple databases including PubMed and Embase.
Analyzed evidence from experimental studies on active compounds and classical formulas.
Focused on the modulation of key signaling pathways related to inflammation, autophagy, and oxidative stress.
TCM was found to inhibit key inflammatory pathways like NF-κB and MAPK.
It promotes metabolic homeostasis via PI3K/Akt and AMPK pathways.
TCM maintains cartilage equilibrium through Wnt/β-catenin and TGF-β/Smad signaling.

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This review demonstrates therapeutic effects of traditional Chinese medicine in osteoarthritis, suggesting its multi-pathway benefits.

Lu et al. (2026) studied this question.

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