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April 23, 2026童綜合醫學雜誌Open Access

Factors associated with local recurrence in patients with oral cancer: A retrospective study from a regional teaching hospital in Central Taiwan

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Authors

CTChin-Hung TsaiHKHsiu Feng KuoJCJieying Chen

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Overview

This retrospective study identifies factors linked to local recurrence in oral cancer, suggesting the need for aggressive treatment.

Key Points

  • This study investigates the clinicopathological factors linked to local recurrence in oral cancer patients post-surgery.
  • Conducted a retrospective cohort study at a single center including patients undergoing primary tumor resection from 2015 to 2022.
  • Analyzed clinicopathological factors and their association with local recurrence using Cox proportional hazard models.
  • Explored the impact of adjuvant therapies and potential predictors for metastasis.
  • A total of 513 patients were studied, with 164 (32%) experiencing local recurrence.
  • Depth of invasion (DOI) of ≥10 mm and cancer stage emerged as independent predictors of recurrence.
  • Significant factors include tumor location, size, histological differentiation, surgical margin status, and receipt of adjuvant therapy.

Cite This Study

Tsai et al. (2026) studied this question.

synapsesocial.com/papers/69e9b9e385696592c86ec5e1https://doi.org/10.4103/etmj.etmj-d-25-00048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors Predicting Recurrence in an Optimally Treated Oral Cancer: Review of 100 Patients of Oral Cancer in North India2026
  2. 2Prognostic factors of oral squamous cell carcinoma: the importance of recurrence and pTNM stage2024 · 45 citations
  3. 3Histopathologic Predictors for Locoregional Recurrence in Patients With Oral Squamous Cell Carcinoma – A Single-Center Retrospective Study2024
  4. 4From Nodal Metastasis to Oncologic Recurrence in Tongue and Oral Floor Squamous Cell Carcinoma: Distinct Failure Patterns and Clinicopathological Risk Profiles2026
  5. 5Analysis of epidemiological and clinicopathological risk factors for locoregional recurrence of oral cavity squamous cell carcinoma: retrospective analysis of 150 patients with buccal mucosal carcinoma in a tertiary care centre2024