Observational evidence shows antihistamines affect sleep and cognition, indicating careful prescription considerations.
Antihistamine effects on sleep and cognition appear to be shaped by both sedative properties and patient characteristics. These findings suggest that prescribing practices should consider both symptom control and potential impacts on sleep health, cognitive performance, and social functioning, while recognizing that causality cannot be inferred without objective assessments and longitudinal designs.
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Jaradat et al. (2026) studied this question.
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