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April 21, 2026The Korean Journal of OrthodonticsOpen Access

Effectiveness of acetaminophen in comparison with ibuprofen for pain control in orthodontic patients: A systematic review and meta-analysis

Nycole Mariana Neves Ádelin Olívia Lopes Joly Rodrigues Giuliana Martina Bordin Ingrid Gomes Perez Occhi‐Alexandre Juliana Schaia Rocha Orsi Marilisa Carneiro Leão Gabardo Francielle Topolski

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Key Points

This research evaluates the effectiveness of acetaminophen compared to ibuprofen for managing pain during orthodontic treatment.
Conducted a systematic review of existing studies on pain control in orthodontic patients.
Performed a meta-analysis to compare outcomes between acetaminophen and ibuprofen.
Pain control effectiveness did not significantly differ between acetaminophen and ibuprofen.
Both medications provided similar relief during orthodontic tooth movement.

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Implication

Systematic review compares pain control outcomes of acetaminophen and ibuprofen in orthodontic patients, suggesting similar effectiveness.

Abstract

Pain control during orthodontic tooth movement did not differ between the two medications.

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Cite This Study

Neves et al. (2026) studied this question.

synapsesocial.com/papers/69e9ba6b85696592c86ec9a5 https://doi.org/10.4041/kjod25.273

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