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Kaur et al. demonstrate how osteoclasts limit inflammasome activation in bone, suggesting a protective mechanism against inflammation.
Ca 2+ flux is a key trigger of NLRP3 inflammasome activation, but bone-resorbing osteoclasts operate in a Ca 2+ -rich environment created during bone resorption. In this issue of Science Signaling , Kaur et al. reveal that osteoclasts prevent inflammasome activation by limiting Ca 2+ influx through the membrane protein Tmem178, thereby protecting bone from excessive resorption driven by inflammatory signaling.
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Schmidt et al. (2026) studied this question.
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