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August 2, 2025Open Access

NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx

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Authors

KKKhushpreet KaurYAYael AlippeCWChun Wang

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Overview

Experimental findings reveal Tmem178's role in calcium regulation and NLRP3 inflammasome suppression in osteoclasts, hinting at potential therapeutic targets.

Key Points

  • Tmem178 regulates NLRP3 inflammasome activation in osteoclasts by inhibiting calcium release from the endoplasmic reticulum.
  • NLRP3 expression decreases during osteoclastogenesis but can be restored with LPS treatment, highlighting its regulatory mechanisms.
  • In vivo results show that high calcium levels enhance inflammasome formation, linking calcium regulation to bone health.
  • Deletion of Nlrp3 alleviates osteopenia in Tmem178 deficient mice, suggesting a protective role against bone loss.

Cite This Study

Kaur et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0355https://doi.org/10.1101/2025.07.28.667255
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Also Consider

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  1. 1Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca <sup>2+</sup> influx2026 · 2 citations
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