What question did this study set out to answer?

This research aims to investigate the functionality of non-decameric NLRP3 species in inflammasome activation pathways.

May 31, 2026Nature CommunicationsOpen Access

Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial shows NLRP3 activation pathways in human macrophages, suggesting complex inflammasome functions.

This research aims to investigate the functionality of non-decameric NLRP3 species in inflammasome activation pathways.
Designed a NLRP3 exon 3 deletion variant to form low molecular weight assemblies.
Utilized high-resolution microscopy to analyze NLRP3 activation in THP-1 and human macrophages.
Identified two activation pathways triggered by nigericin in human neutrophils.
Two distinct NLRP3 activation pathways were delineated: a rapid decameric cage-dependent pathway and a TGN/MTOC-distal slow-reacting pathway.
The cage-independent pathway dominated in human neutrophils, indicating its biological significance.

Tortola et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark