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November 12, 2025Orthodontics and Craniofacial ResearchOpen Access

The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement

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Authors

LLLisa LatzkoGDGerald DegenhartMBMichael J. Blumer

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Overview

Analysis reveals that NLRP3 impacts tooth movement and osteoclast activity in wild-type mice following orthodontic treatment.

Key Points

  • Mice lacking NLRP3 showed delayed orthodontic tooth movement after two weeks, catching up by day 21.
  • Micro-computed tomography assessed tooth movement and bone quality in NLRP3 −/− and wild-type mice.
  • Osteoclast activity was visualized using tartrate-resistant acid phosphatase staining in both mouse types.
  • NLRP3 appears critical during early stages of orthodontic tooth movement, influencing alveolar bone loss.

Cite This Study

Latzko et al. (2025) studied this question.

synapsesocial.com/papers/692523d9c0ce034ddc355813https://doi.org/10.1111/ocr.70059
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  1. 1NLRP3 Inflammasome Activation During Acute Negative Pressure Injury in the Middle Ear of Mice2024
  2. 2Neutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement2026
  3. 3Identification of novel candidate immune biomarkers linked to osteoclast activity during orthodontic tooth movement in a mouse model2025
  4. 4Emerging Role of the NLRP3 Inflammasome in the Onset of Oral Diseases and Its Potential as a Therapeutic Target2026 · 5 citations
  5. 5Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca <sup>2+</sup> influx2026 · 2 citations