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April 23, 2026Journal of Cutaneous Pathology

Cutaneous Manifestation of Monomorphic Epitheliotropic Intestinal T‐Cell Lymphoma: A Clue to A Gastrointestinal Malignancy

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Authors

FCFan Foon CheoSingapore General HospitalAFAashna FarishtaRush University Medical CenterBGBriana M. GarciaUniversity of California, San Francisco

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Implication

Case report highlights cutaneous involvement as a sign of gastrointestinal malignancy, suggesting the need for further evaluation.

Key Points

  • This case illustrates the rare cutaneous manifestations of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL).
  • A 68-year-old man with initial cutaneous lesions underwent multiple biopsies and staging with PET/CT and bone marrow biopsy.
  • Histopathologic examination identified atypical T-lymphocytes in skin and subsequently in tongue and jejunum biopsies.
  • Initial skin biopsy revealed atypical CD8+/CD56+/TCR-δ-/EBER- T-lymphocytes with slight epidermotropism.
  • Later biopsies of the tongue and jejunum showed similar infiltrates, confirming a diagnosis of MEITL.
  • The absence of gluten-sensitive enteropathy and supportive pathology led to final diagnosis, indicating systemic involvement.

Cite This Study

Cheo et al. (2026) studied this question.

synapsesocial.com/papers/69e9baeb85696592c86ecd93https://doi.org/10.1111/cup.70123
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Also Consider

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  1. 1The 2016 revision of the World Health Organization classification of lymphoid neoplasms2016 · 7,965 citations
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  4. 4Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project2011 · 364 citations