What question did this study set out to answer?

To investigate the significance of the claustrum sign in diagnosing Hashimoto's encephalopathy presenting with NORSE.

April 23, 2026Clinical Case Reports0 citationsOpen Access

Claustrum Sign in Hashimoto Encephalopathy Presenting With New Onset Refractory Status Epilepticus ( NORSE ): First Report of a Rare Phenotype

ZMZahra‐Sadat Mirian MNMohammad Amin Najafi MNMohammad Amin Najafi

Key Points

To investigate the significance of the claustrum sign in diagnosing Hashimoto's encephalopathy presenting with NORSE.
Case report detailing the presentation and diagnosis of a patient with NORSE and the claustrum sign.
Clinical assessment including imaging and treatment response analysis.
Identification of the bilateral claustrum sign in a patient with new-onset refractory status epilepticus.
Successful treatment with corticosteroids, leading to clinical improvement.

Abstract

ABSTRACT The presence of the bilateral claustrum sign in new‐onset refractory status epilepticus (NORSE) should prompt consideration of Hashimoto's encephalopathy, even without thyroid dysfunction. Early recognition and corticosteroid therapy can be lifesaving, emphasizing an autoimmune‐inflammatory mechanism underlying this rare presentation.

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