Key result
Essential hypertension is reframed as a systemic repair failure syndrome driven by Tissue Pressure Dysregulation Factor exceeding homeostatic repair capacity.
Why the study?
To apply the definitive TOFD > C paradigm to essential hypertension and frame it as a systemic repair failure syndrome rather than idiopathic primary hypertension.
Design
Theoretical framework
Proposes a novel theoretical framework for essential hypertension based on the 9-Keel TOFD Theoretical System, challenging the traditional idiopathic narrative.
This work is Paper 5 of the 9-Keel Unified Theory Series, applying the definitive TOFD > C paradigm (DOI: 10.5281/zenodo.19676866) to Essential Hypertension. It frames hypertension as a systemic repair failure syndrome driven by Tissue Pressure Dysregulation Factor (TPDF) exceeding homeostatic repair capacity (C, defined as the Ang Constant), rejecting the traditional "idiopathic primary hypertension" narrative. The work adheres to the core axiom: "Cells have no subjective will, no self-attack behavior, no pathological rebellion."
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FOO SENG ANG (2026) studied this question. Essential hypertension is reframed as a systemic repair failure syndrome driven by Tissue Pressure Dysregulation Factor exceeding homeostatic repair capacity.
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