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January 1, 2026RSC Medicinal Chemistry

Synthesis-guided design and discovery of alkylated indoles with antibacterial activity against MRSA

Auqib Rashid Vishwani Jamwal Bilal A. Bhat Kuljit Singh Showkat Rashid

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Key Points

The aim is to design and synthesize alkylated indoles to assess their effectiveness against MRSA.
Utilized synthesis-guided design for creating alkylated indole compounds.
Tested the antibacterial activity against MRSA strains.
Analyzed structure-activity relationships to determine effective compounds.
Identified several alkylated indoles with significant antibacterial properties against MRSA.
Demonstrated effectiveness that could potentially surpass current treatments.
Highlighted the role of specific structural features in enhancing antibacterial activity.

Implication

Research uncovers the antibacterial effects of alkylated indoles against MRSA, indicating a potential new strategy in overcoming drug resistance.

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Cite This Study

Rashid et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb9e85696592c86ed27c https://doi.org/10.1039/d6md00221h

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Synthesis of Bisindole Alkaloids and Their Mode of Action against Methicillin-Resistant <i>Staphylococcus Aureus</i>2024 · 9 citations
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5Synthesis and Antibacterial Evaluation of Novel Small-Molecule Antibacterials of a Reduced Acridine Structure in S. aureus Strains Including MRSA2024 · 1 citations

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