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April 23, 2026ChemistryOpen0 citationsOpen Access

Self‐Assembly Behavior of Monodisperse PEG Amphiphiles Bearing Hydrophobic Units with Distinct Molecular Shapes in Water

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AKAi KohataTokyo Institute of TechnologyRHRei HamaguchiTokyo Institute of TechnologyKKKazushi KinbaraTokyo Institute of Technology

Key Points

  • Investigating how the shape of hydrophobic units influences the self-assembly behavior of amphiphiles in water.
  • Synthesis of octaethylene glycol (OEG)-appended amphiphiles with varying hydrophobic unit shapes
  • Characterization of self-assembly behaviors in pure water
  • Observation of formed structures such as liquid droplets and nanosheets
  • Different hydrophobic unit shapes led to the formation of distinct self-assembled structures
  • Resulting assemblies included liquid droplets, nanosheets, and supramolecular oligomers
  • Demonstrated the critical role of molecular shape in amphiphile design.

Abstract

The shape of hydrophobic units on the self-assembly of amphiphiles in pure water remains underexplored. In this work, three types of octaethylene glycol (OEG)-appended amphiphiles bearing propeller-shaped, twisted, and planar hydrophobic units were synthesized. They formed different types of assemblies, such as liquid droplets, nanosheets, and supramolecular oligomers, suggesting the importance of molecular shape in designing the self-assembly of amphiphiles in water.

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Cite This Study

Kohata et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb9e85696592c86ed3e0https://doi.org/10.1002/open.70214
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