Biogenic chitosan anchored Cu ₂ O/ZnO nanocomposite: unlocking synergy for drug delivery, antineoplastic action, and wound repair

Q: What does this research mean for the field?

Green-synthesized chitosan-anchored Cu2O/ZnO nanocomposites provide highly efficient cisplatin release, selective toxicity against A375 melanoma cells with minimal fibroblast damage, and accelerated wound healing. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Manojna R. Nayak; Ravindra R. Kamble; Lokesh Bheemayya; Vishwa B. Nadoni; Amruta Patri; Mallika Wali; Arun K. Shettar; Joy H. Hoskeri; Rangappa S. Keri; Ashok M. Sajjan

doi:10.1039/d5pm00392j

January 1, 2026RSC PharmaceuticsOpen Access

Biogenic chitosan anchored Cu ₂ O/ZnO nanocomposite: unlocking synergy for drug delivery, antineoplastic action, and wound repair

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Key Points

The aim is to evaluate the effectiveness of biogenic chitosan anchored Cu2O/ZnO nanocomposite for drug delivery and wound repair.
Green synthesis of Cu2O/ZnO nanocomposite using S. campanulata fluid.
Analysis of cisplatin release at 72 hours.
Assessment of cytotoxicity on A375 melanoma and fibroblast cells.
Achieved 94.88% cisplatin release within 72 hours.
Demonstrated selective toxicity towards A375 melanoma cells with minimal fibroblast damage.
Showed significant enhancement in wound healing.

Implication

Green-synthesized nanocomposite shows promising effects on drug delivery and tissue repair in targeted cancer therapy, indicating medical potential.

Abstract

Green-synthesized CS-Cu 2 O/ZnO NCs using S. campanulata fluid (WCF) offer 94.88% cisplatin release at 72h. They show selective A375 melanoma toxicity, low fibroblast damage, and fast wound healing, proving ideal for targeted cancer therapy and repair.

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Cite This Study

Nayak et al. (2026) studied this question.

synapsesocial.com/papers/69e9bc1285696592c86ed4b3 https://doi.org/10.1039/d5pm00392j

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Biogenic chitosan anchored Cu ₂ O/ZnO nanocomposite: unlocking synergy for drug delivery, antineoplastic action, and wound repair

Key Points

Implication

Abstract

Discussion

Cite This Study

Biogenic chitosan anchored Cu ₂ O/ZnO nanocomposite: unlocking synergy for drug delivery, antineoplastic action, and wound repair

Key Points

Implication

Abstract

Discussion

Cite This Study

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