The ARIC prospective cohort of 15,792 Black and White adults has produced over 2,300 publications identifying determinants of subclinical atherosclerosis and coronary heart disease.
Cohort (n=15,792)
Yes
The ARIC study is a landmark prospective cohort that has significantly advanced the understanding of cardiovascular disease determinants, health disparities, and prevention over several decades.
ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, genomics, heart failure, and prevention, producing more than 2,300 publications. Results have had strong clinical impact and demonstrate the importance of population-based research in the spectrum of biomedical research to improve health.
“You can't really understand risk factors for long-term outcomes unless you follow people for 20 or 30 years, so it's really an extraordinary study.”
Wright et al. (2021) conducted a cohort in Coronary heart disease and subclinical atherosclerosis (n=15,792). The ARIC prospective cohort of 15,792 Black and White adults has produced over 2,300 publications identifying determinants of subclinical atherosclerosis and coronary heart disease.