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Studies of epithelio-mesenchymal interactions during embryonic organogenesis have led to a number of conclusions regarding (he nature of cellular and tissue differentiation (McLoughlin, 1963; Grobstein, 1967). For example, the importance of both the epithelium and the mesenchyme and the dependence of some systems on a limited number of specific mesenchymal tissues have been pointed out (Hilfer, 1968).
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Kollar et al. (1969) studied this question.
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