December 7, 2017Human Gene Therapy MethodsOpen Access

Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice

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Authors

CGCarolina GándaraNewcastle University VAValerie AffleckBrooklyn Navy Yard ESElizabeth A. StollSchool of Advanced Study

Discussion

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Implication

Supports preclinical lentiviral production; leaves open GMP translation for clinical gene therapy trials.

Structured PICO

Intervention

Manufacture of high-titer third-generation lentivirus

This paper provides a detailed protocol and translational considerations for manufacturing third-generation lentiviral vectors for preclinical and clinical gene therapy applications.

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Gándara et al. (2017) studied this question.

synapsesocial.com/papers/69ea03fe82f9ea2dfdccf6e4 https://doi.org/10.1089/hgtb.2017.098

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Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider